SPI configuration with master and a slave. This article focuses on the popular 4-wire SPI interface. The SPI interface can be either 3-wire or 4-wire. Both master and slave can transmit data at the same time. The data from the master or the slave is synchronized on the rising or falling clock edge. SPI is a synchronous, full duplex master-slave-based interface. This article provides a brief description of the SPI interface followed by an introduction to Analog Devices’ SPI enabled switches and muxes, and how they help reduce the number of digital GPIOs in system board design. Serial peripheral interface (SPI) is one of the most widely used interfaces between microcontroller and peripheral ICs such as sensors, ADCs, DACs, shift registers, SRAM, and others.